Neuraxial Opioid Kinetics: Spinal & Epidural Analgesia for Regional Anaesthesia

In this explainer episode of GasGasGas, we make our descent into the joyful complexities of neuraxial opiate pharmacology. Why do we bother putting opiates into this space at all? What governs their journey, how do they behave once administered, and what clinical pearls can be drawn from their behaviour? This episode follows the journey of a single opioid molecule through the fatty labyrinth of the epidural space, across barriers, and into its final destination: the dorsal horn of the spinal cord, before it potters away to realms of mischief in the brainstem. Show notes at: https://gasgasgas.uk/neuraxial-opiate-kinetics-for-the-frca-primary/ ================================================ GasGasGas - Covering Anaesthetic Science for Anaesthetists! Sponsored by Teach Me Anaesthetics Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate] Contributions to keep the lamps lit here ================================================ Dr Gas Lurks On:  > BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social) > X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X > FaceBook: Facebook - Gas Gas Gas > Website: www.gasgasgas.uk ================================================ Disclaimer / Sage Advice > All content is educational in nature and never intended to be acted upon. > This information is not a suitable substitute for medical advice. > Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed.  > Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present. ================================================ Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive  Sassy Jazzy - La Faena - Free music archive ================================================ "This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder." © GasGasGas-Podcast 2025